RESUMO
The generation of ROS underlies all solar infrared-affected therapeutic and pathological cutaneous effects. The signaling pathway NF-kB is responsible for the induced therapeutic effects, while the AP-1 for the pathological effects. The different signaling pathways of infrared-induced ROS and infrared-induced heat shock ROS were shown to act independently multiplying the influence on each other by increasing the doses of irradiation and/or increasing the temperature. The molecular action mechanisms of solar infrared radiation and heat on human skin are summarized and discussed in detail in the present paper. The critical doses are determined. Protection strategies against infrared-induced skin damage are proposed.
Assuntos
Temperatura Alta/efeitos adversos , Raios Infravermelhos/efeitos adversos , Estresse Oxidativo/efeitos da radiação , Espécies Reativas de Oxigênio/metabolismo , Pele/efeitos da radiação , Animais , Antioxidantes/farmacologia , Humanos , NF-kappa B/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Medição de Risco , Fatores de Risco , Transdução de Sinais/efeitos da radiação , Pele/efeitos dos fármacos , Pele/metabolismo , Fator de Transcrição AP-1/metabolismoRESUMO
We studied the effects of taurine, carnosine, and casomorphine on histamine release from rat peritoneal mast cells induced by compound 48/80 and ionophore A23187. Differences were revealed in the effect of the test preparations. Taurine inhibited histamine release induced by ionophore A23187, but not by compound 48/80. Carnosine abolished the stimulatory effect of compound 48/80 on histamine release, but did not modulate the effect of ionophore A23187. Casomorphine inhibited histamine release induced by ionophore A23187, but potentiated the effect of compound 48/80. The mechanisms for these effects are discussed.
Assuntos
Carnosina/farmacologia , Endorfinas/farmacologia , Mastócitos/efeitos dos fármacos , Fragmentos de Peptídeos/farmacologia , Cavidade Peritoneal/citologia , Taurina/farmacologia , Animais , Calcimicina/farmacologia , Liberação de Histamina/efeitos dos fármacos , Masculino , Mastócitos/citologia , Ratos , Ratos Wistar , p-Metoxi-N-metilfenetilamina/farmacologiaRESUMO
We studied the effect of ultraviolet B irradiation on superoxide dismutase activity, ceruloplasmin level in the plasma, and steroid hormone concentration in the adrenal glands of C57Bl/6 mice subjected to immobilization stress. Ultraviolet B irradiation did not abolish the increase in superoxide dismutase activity, but decreased ceruloplasmin level in the plasma and corticosteroid concentration in the adrenal glands of mice exposed to immobilization stress.
Assuntos
Imobilização/fisiologia , Estresse Fisiológico/metabolismo , Raios Ultravioleta/efeitos adversos , Corticosteroides/metabolismo , Glândulas Suprarrenais/metabolismo , Animais , Ceruloplasmina/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Superóxido Dismutase/metabolismoRESUMO
We studied the effect of short-term swimming in cold water (13 degrees C) on parameters of the blood antioxidant system (activities of superoxide dismutase and catalase, concentrations of ceruloplasmin and nonprotein thiols), heme oxygenase activity, and nonprotein thiol level in mouse liver. The test parameters of antioxidant protection increased 1 h after cold exposure and remained high 1 day after treatment. These changes were accompanied by an increase in the adaptive capacity. After swimming in cold water the resistance of animals to another stress factor (administration of epinephrine) was higher compared to controls.
